血清胱抑素C在不稳定性心绞痛患者中的临床意义

发布时间：2018-01-29 18:40:17 来源：文档文库

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血清胱抑素C在不稳定性心绞痛患者中的临床意义
作者：唐杰
来源：《中国医药导报》2016年第11期

[摘要] 目的探讨血清胱抑素C（Cys-C）在不稳定性心绞痛患者中的临床意义。方法选取2012年9月～2015年3月四川省广元市第二人民医院收治的不稳定性心绞痛患者154例，按照Braunwald分级分为Ⅰ级组（n=51）、Ⅱ级组（n=48）、Ⅲ级组（n=55）；选取同期60例健康者作为正常组。对比四组患者血清Cys-C、超敏C反应蛋白（hs-CRP）、脑钠肽（BNP）水平；随访6个月，观察四组心脏不良事件的发生情况。结果 Ⅰ级组、Ⅱ级组、Ⅲ级组血清Cys-C、hs-CRP、BNP水平均显著高于正常组，差异有高度统计学意义（P < 0.01）；随着Braunwald等级升高，患者血清Cys-C、hs-CRP、BNP水平也随之升高，差异有高度统计学意义（P < 0.01）。直线相关性分析显示，血清Cys-C水平与hs-CRP、BNP均呈正相关（r=0.374、0.518，P < 0.05）。四组心脏不良事件发生率比较，差异有高度统计学意义（P < 0.01）；随着Braunwald等级升高，患者心脏不良事件发生率也逐渐升高，差异有统计学意义（P < 0.05）。结论血清Cys-C水平与不稳定性心绞痛的严重程度呈正相关关系，对患者预后具有指导意义。

[关键词] 胱抑素C；不稳定性心绞痛；超敏C反应蛋白；脑钠肽

[中图分类号] R541.4 [文献标识码] A [文章编号] 1673-7210（2016）04（b）-0072-04

[Abstract] Objective To investigate clinical significance of serum cystatin C （Cys-C） in patients with unstable angina. Methods 154 patients with unstable angina were selected from September 2012 to March 2015 in the Second People′s Hospital of Guangyuan City， Sichuan Province. 154 patients were divided into three groups according to Braunwald grade： grade Ⅰ group （n=51）， grade Ⅱ group （n=48） and grade Ⅲ group （n=55）. 60 healthy persons in the same period were selected as normal group. The levels of serum Cys-C， hs-CRP and BNP in four groups were compared. Followed up for 6 months， the occurrence of adverse cardiac events in four groups were observed. Results Levels of serum Cys-C， hs-CRP， BNP in grade Ⅰ group， grade Ⅱ group and grade Ⅲ group were significantly higher than those in normal group， the differences were significantly （P < 0.01）. With the increase of Braunwald grade， levels of serum Cys-C， hs-CRP and BNP were significantly increased in patients， the differences were significantly （P < 0.01）. Linear correlation analysis showed that serum Cys-C level was positively correlated with hs-CRP and BNP （r=0.374， 0.518， P < 0.05）. There was significant difference on incidence rate of cardiac adverse events in four groups （P < 0.01）. With the increase of Braunwald grade， the incidence rate of cardiac adverse events were gradually increased in patients， the differences were significantly （P < 0.05）. Conclusion Level of serum Cys-C is positively correlated with the severity of unstable angina， it has a guiding significance for prognosis of patients.