>>>>当代医学2017年2月第23卷第04期总第447期ContemporaryMedicine,Feb.2017,Vol.23No.04IssueNo.447
doi:10.3969/j.issn.1009-4393.2017.04.001
--论著--
银杏酮酯滴丸治疗颈动脉粥样硬化斑块的临床研究
陈焕清,符少萍,陈玉成,缪瑞明
(中山大学孙逸仙纪念医院,广东广州510120)
摘要:目的探讨银杏酮酯滴丸对颈动脉粥样硬化斑块干预治疗的临床疗效及其机制。方法选取脑梗死并颈动脉粥样硬化患者92例,随机分成对照组和观察组,每组46例,对照组在常规治疗的基础上予以瑞伐他汀治疗;观察组在对照组的基础上再加用银杏酮酯滴丸治疗,治疗期均为6个月,测定每例患者治疗前后血脂、血糖、肝肾功能、肌酶、hs-CRP、MMP-9及颈动脉IMT、斑块大小、数量、面积等,采用SPSS11.0统计软件进行分析。结果观察组患者治疗后血中TC、TG、LDL-C及hs-CRP、MMP-9的水平均显著低于对照组同期,分别为(4.52±0.47)VS(5.29±0.51),(1.75±0.21)VS(2.01±0.22),(2.50±0.22)VS(2.90±0.27),(3.12±0.67)VS(4.21±0.72),(180.7±7.4)VS(281.2±9.1)(P<0.05),观察组患者治疗后IMT及斑块积分显著低于对照组同期(0.87±0.15)VS(1.14±0.19),(3.12±0.35)VS(4.62±0.42)(P<0.05)。结论银杏酮酯滴丸治疗颈动脉粥样斑块的临床疗效显著,安全性好。其作用机制可能与其抑制体内炎症因子有关。
关键词:银杏酮酯滴丸;动脉粥样硬化;斑块;瑞伐他汀;治疗;机制
ClinicalstudyonYinXingGuttatedroppingPillsintreatmentofcarotidarteryatheromatousplaque
ChenHuan-qing,FuShao-ping,ChenYu-cheng,MiaoRui-ming
(DepartmentofHealthCare,ThesecondaffiliatedHospitalofSunyat-senUniversity,Guangzhou,Guangdong,510120,ChinaAbstract:ObjectiveToobservetheclinicaleffectandthemechanismofYinXingGuttateDroppingPillsintreatmentofcarot-idarteryatheromatousplaque.MethodsPatients(92caseswithcarotidarteryatheromatousplaquewererandomlydividedintocon-trolandtreatmentgroups,andeachgrouphad30cases.ThepatientsinthecontrolgroupwerepoadministeredwithRosuvastatincal-ciumTablets,1tablet/time,oncedaily,onthebasistreatmentofcarotidarteryatheromatous.ThepatientsinthetreatmentgroupwerepoadministeredwithYinXingGuttateDropping