CD4+CD25+调节性T细胞在急性淋巴细胞白血病患者中的变化研究

发布时间：2014-06-10 14:33:27 来源：文档文库

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CD4+CD25+调节性T细胞在急性淋巴细胞白血病患者中的变化研究
作者：黎民君郭丽堃陈利媚冯思琼
来源：《中国现代医生》2013年第07期

[摘要] 目的对急性白血病（ALL）患者CD4+CD25+调节性T细胞变化进行研究。方法 26例化疗后完全缓解的ALL患者为完全缓解组，20例初次治疗的急性淋巴细胞白血病患者为初治组，另选择20例健康志愿者为对照组，检测各组调节性T细胞的变化。结果完全缓解组和对照组外周血CD4+CD25+调节性T细胞水平明显低于初治组，差异有统计学意义（P < 0.05）。完全缓解组与对照组比较，无统计学差异（P > 0.05）。结论急性淋巴细胞白血病患者的CD4+CD25+调节性T细胞检测具有一定的临床意义，为白血病的诊断和治疗提供了依据。

[关键词] CD4+CD25+调节性T细胞；急性淋巴细胞白血病；细胞免疫；肿瘤细胞

[中图分类号] R392.4 [文献标识码] B [文章编号] 1673-9701（2013）07-0040-02

Research on change of CD4+CD25+ regulatory T cells in patients with acute lymphoblastic leukemia

LI Minjun GUO Likun CHEN Limei FENG Siqiong

Department of Haematology， the People's Hospital of Meizhou City in Guangdong Province，Meizhou 514000，China

[Abstract] Objective To study the change of CD4+CD25+regulatory T cells in patients with acute lymphoblastic leukemia（ALL）. Methods A total of 26 patients with complete remission after chemotherapy were studied as complete remission group，20 patients with initial treatment were as initial treatment group，and the other 20 healthy volunteers were as control group，the change of regulatory T cells in each group was detected. Results CD4+CD25+ regulatory T cells levels in the complete remission group and control group were significantly lower than that in the initial treatment group，there were statistically significant （P < 0.05）.About the CD4+CD25+ regulatory T cells level in the complete remission group and the control group，there was not significant （P > 0.05）. Conclusion There is certain clinical significance about CD4+CD25+ regulatory T cells level in the patients with acute lymphoblastic leukemia.It provides a basis for the diagnosis and treatment of leukemia.